The Calcimimetic Agent AMG 073 Lowers Plasma Parathyroid Hormone Levels in Hemodialysis Patients with Secondary Hyperparathyroidism
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چکیده
منابع مشابه
The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism.
Treatment with vitamin D sterols can lower plasma parathyroid hormone (PTH) in many patients with secondary hyperparathyroidism due to end-stage renal disease, but hypercalcemia, hyperphosphatemia, or both often develop during treatment. As such, alternative therapeutic approaches to managing excess PTH secretion are needed. Calcimimetic agents directly inhibit PTH secretion by activating the c...
متن کاملThe correlation of heart rate variability with parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism
Introduction: Hyperparathyroidism (HPTH) which is often found in end stage of chronic renal disease patients replaced by hemodialysis (HD) may cause the cardiac autonomic neuropathy. Method: Healthy subjects and HD patients categorized into two groups by parathyroid hormone (PTH) levels: high PTH group (H-PTH; PTH = 150 300 pg/mL) and ultra high PTH group (UH-PTH; PTH > 300 pg/mL) were investig...
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INTRODUCTION In end-stage renal disease, there is a high incidence of secondary hyperparathyroidism. It is proposed that increasing vitamin C levels by dietary supplementation results in a decrease of parathyroid hormone (PTH) in vitamin C-deficient hemodialysis patients with secondary hyperparathyroidism. The aim of this study was the evaluation of vitamin C administration for reduction of ser...
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We evaluated the improvement of intact parathyroid hormone (iPTH) levels and bone parameters by supplementing nutritional vitamin D (cholecalciferol) to combined calcimimetic (cinacalcet) and active vitamin D analog (calcitriol) among severe secondary hyperparathyroidism (SHPT) hemodialysis (HD) patients. A randomized, controlled open-label study was undertaken in 60 HD patients with serum iPTH...
متن کاملThe Relationship of Intact Parathyroid Hormone and Ionised Calcium in Secondary Hyperparathyroidism among Hemodialysis Patients
The parathyroid hormone (PTH) is a 115 amino acid precursor molecule; the intact PTH (iPTH) contains only 84 amino acids which is biologically active molecule. The PTH helps in regulation of serum calcium levels, either hyper or hypocalcaemia causes release of PTH. It regulates the serum calcium levels by increasing the flow of calcium from bone to extracellular fluid, by increasing the re-abso...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2002
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v1341017